Bioapigyn® pessaries

Composition: oil extract of the plant species: marigold flowers (Calendula officinalis L.), plantain leaves (Plantago major L.), chamomile flowers (Matricaria chamomilla L.), aerial part of St. John’s Wort (Hypericum perforatum L.), comfrey root (Symphytum officinale L.), lavender flowers (Lavandula officinalis L.), aerial part of yarrow (Achillea millefolium L.), aerial part of wild thyme (Thymus serpyllum L.), aerial part of sage (Salvia officinalis L.), mint leaves (Mentha piperita L.), lady’s mantle leaves (Alchemilla vulgaris L.),olive leaves (Olea europaea L.); essential oils: tea tree (Melaleuca alternifolia), thyme (Timus vulgaris) ct. thymol, ravensara (Cinnamomum camphora ct. cineol), palmarosa (Cympobogon martini), oregano (Origanum vulgare) and clove (Eugenia caryophyllata); beeswax (Cera alba); Witepsol E75. 100% natural product!!! No artificial preservatives, colorants and fragrances!!!

Mode of action: The additive and synergistic effects of bioactive compounds from oil macerates and essential oils of the selected medicinal plants result in the antimicrobial and anti-viral activity, anti-inflammatory effect as well as positive effect on wound healing and re-epithelialization of the cervical cells. Oil macerates and essential oils maintain a favorable micro-climate of the vagina due to the prevention of dryness of the mucous membranes and creation of the protective layer. The product is soluble at body temperature ensuring excellent coating of the genital tract mucosa and prevents irritation. The optimal retention of the pessary in the vagina was achieved by optimizing the ratio of beeswax to Whitepsol E75. Pessary is sufficiently compact and solid, ensuring its integrity during the removal from the blister. The selection of appropriate base components (beeswax and hard fat) ensures that the texture of the pessary does not irritate the lining of the genital tract during the application. The oil extracts and essential oils have also a deodorizing effect which removes the odor of some pathological conditions.

Indications: Bioapigyn®  pessaries are intended for use as a primary therapy for the treatment of cervical metaplasia, as additional therapy for the treatment of cervical intraepithelial neoplasia, as a primary therapy for the prevention of antibiotic’s associated fungal infections, for the treatment of wounds after surgery, childbirth and radiation therapy, for the treatment of the existing fungal infection caused by Candida species, as primary or additional therapy for treatment of bacterial vaginosis, as additional therapy for the treatment of the infections of the female lower genital tract caused by Ureaplasma, Mycoplasma and Chlamydia, as additional therapy in the treatment of HPV infection and genital herpes. It is also intended for relief of the symptoms such as itching, vaginal discharge, vaginal dryness and unpleasant odor. It is ideal for the treatment of atrophic changes, and vaginal dryness of perimenopausal and menopausal women.

Dosage and administration: Bioapigyn pessaries are intended for vaginal use. Separate both sides of the foil at the top and remove the pessary from the package with clean fingers. Use a finger to insert the pessary into the vagina. Use one pessary per day, preferably before bedtime. For the treatment of cervical metaplasia and bacterial vaginosis, use the pessaries once a day for two weeks. For the prevention of antibiotics’ associated yeast infection use the pessaries during the taking antibiotics’ therapy. To relieve menopausal symptoms use the pessaries where necessary. For all other indications use the pessaries at least 30 days.

Precautions: Do not use during the pregnancy and breastfeeding. The recommended daily dose must not be exceeded. Do not use in case of hypersensitivity to any component of the product.

Storage instructions: at the temperature below 250C, out of the reach of children.

Packaging: a box contains 10 pessaries of 3 g in a strip.

Formulated by: prof. dr. sc. Višnja Oreščanin

Patent: HR: P20150876A